ATG7 anticorps (N-Term)

N° du produit ABIN497975

L’anticorps Lapin Polyclonal anti-ATG7 a été validé pour WB, IF et EIA. Il convient pour détecter ATG7 dans des échantillons de Humain et Souris.

Aperçu rapide pour ATG7 anticorps (N-Term) (ABIN497975)

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG7 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-ATG7 anticorps

Épitope: N-Term

Specificité: Recognizes APG7L/ATG7 (N-term).

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Immunoaffinity Chromatography

Immunogène: APG7 antibody was raised against a 17 amino acid peptide from near the amino terminus of Human APG7.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: APG7 antibody can be used for the detection of APG7 at 1-2 μg/mL. Positive Control: L1210 Cell Lysate. Immunocytochemistry. Positive Control: L1210 Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ATG7

Antigène: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Autre désignation: APG7L / ATG7

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme, this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5). It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6).Synonyms: APG7-like, Autophagy-related protein 7, Ubiquitin-activating enzyme E1-like protein

ID gène: 10533

NCBI Accession: NP_006386

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagy